Generic Name for TAXOL
Paclitaxel 6mg/mL; soln for IV infusion after dilution; contains Cremophor EL (polyoxyethylated castor oil), dehydrated alcohol.
Legal Classification:
Rx
Pharmacological Class for TAXOL
Antimicrotubule agent.
Manufacturer of TAXOL
Bristol-Myers Squibb
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Indications for TAXOL
First-line therapy (in combination with cisplatin) and subsequent therapy for advanced carcinoma of the ovary.
Other Indications for TAXOL
Adult dose for TAXOL
See literature. Premedicate with corticosteroids, diphenhydramine, H2 antagonists. Previously untreated ovarian cancer: 175mg/m2 IV over 3 hours + cisplatin every 3 weeks; or 135mg/m2 IV over 24 hours + cisplatin every 3 weeks. Previously treated ovarian cancer: 135mg/m2 or 175mg/m2 IV over 3 hours every 3 weeks. Hepatic impairment or neutropenia: see literature for dose modifications. Do not treat if neutrophil count <1,500cells/mm3 or platelets <100,000cells/mm3.
Children's dosing for TAXOL
Not recommended.
Contraindications for TAXOL
Baseline neutrophil count <1,500cells/mm3.
Warnings/Precautions for TAXOL
Do frequent peripheral blood cell counts. Hepatic dysfunction. Conduction abnormalities: monitor cardiac function. Avoid extravasation. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Interactions for TAXOL
May potentiate or be potentiated by CYP2C8 or CYP3A4 substrates, inducers and/or inhibitors. Potentiated by cisplatin. May potentiate doxorubicin.
Adverse Reactions for TAXOL
Bone marrow suppression (eg, neutropenia, leukopenia, thrombocytopenia, anemia), inj site reactions, infections, hypotension, bradycardia, hypersensitivity reactions (if severe, do not rechallenge), peripheral neuropathy, myalgia, arthralgia, GI upset, mucositis, alopecia, abnormal ECG, elevated liver enzymes.
How is TAXOL supplied?
Multidose vial (5mL, 16.7mL, 50mL)—1