HEXALEN

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Generic Name for HEXALEN

Altretamine 50mg; caps.

Legal Classification:

Pharmacological Class for HEXALEN

S-triazine derivative.

Manufacturer of HEXALEN

MGI Pharma, Inc.

Indications for HEXALEN

Palliative treatment of persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.

Adult dose for HEXALEN

260mg/m² daily in four divided doses (after meals and at bedtime), for either 14 or 21 consecutive days in a 28-day cycle. Discontinue for >14 days if GI intolerance is unresponsive to treatment, WBC count <2000/mm³ or granulocyte count <1000/mm³, platelet count <75000/mm³, or progressive neurotoxicity occurs. Restart at 200mg/m² daily. Discontinue indefinitely if neurologic symptoms fail to stabilize.

Children's dosing for HEXALEN

Not recommended.

Contraindications for HEXALEN

Severe myelosuppression or neurologic toxicity, except cisplatin-related neuropathy.

Warnings/Precautions for HEXALEN

Monitor for myelosuppression (do monthly CBCs) and neurotoxicity. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions for HEXALEN

Avoid pyridoxine. Severe orthostatic hypotension with MAOIs.

Adverse Reactions for HEXALEN

Nausea, vomiting, peripheral neuropathy, CNS symptoms (eg, mood disorders, ataxia, dizziness), myelosuppression, renal dysfunction, increased alkaline phosphatase.

How is HEXALEN supplied?

Caps—100

Related Disease:

Cancer, ovarian

Data provided by the Monthly Prescribing Reference (MPR) Hematology/Oncology Edition.

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