Generic Name for DOXIL
Doxorubicin HCl (liposomal) 2mg/mL; dispersion for IV infusion after dilution; preservative-free.
Legal Classification:
Rx
Pharmacological Class for DOXIL
Anthracycline.
Manufacturer of DOXIL
Janssen Biotech, Inc.
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Indications for DOXIL
Ovarian cancer refractory to platinum-based chemotherapy.
Other Indications for DOXIL
Adult dose for DOXIL
Give by IV infusion at initial rate of 1mg/min; may increase rate to complete infusion over 1 hour if no infusion reactions occur; may premedicate with antiemetics. 50mg/m2 once every 4 weeks; continue for at least 4 cycles as tolerated. Hepatic dysfunction (serum bilirubin ≥1.2mg/dL), hand-foot syndrome, hematologic toxicity (esp. ANC, platelets), or stomatitis: reduce dose. Consider total anthracycline and anthracenedione doses and irradiation when calculating total cumulative dose. See literature.
Children's dosing for DOXIL
Not recommended.
Contraindications for DOXIL
Pregnancy (Cat.D); nursing mothers: not recommended.
Warnings/Precautions for DOXIL
Not substitutable on a mg/mg basis with other doxorubicin products. Have resuscitative/antiallergic equipment and expertise available. Avoid extravasation. Monitor blood (esp. CBC + platelets, hepatic (esp. SGOT/SGPT, alkaline phosphatase), and cardiac function (esp. myocardial biopsy).
Interactions for DOXIL
Caution with cyclosporine, phenobarbital, phenytoin, streptozocin, digoxin, myelosuppressants, others. Previous mediastinal irradiation, cyclophosphamide, other cardiotoxic drugs: monitor for cardiotoxicity and hepatotoxicity.
Adverse Reactions for DOXIL
GI upset, fever, alopecia, myelosuppression, stomatitis, infusion reaction (eg, back pain, flushing, dyspnea, hypotension), hand-foot syndrome, cardiovascular events (eg, cardiomyopathy, CHF, acute LV failure), recall of skin reaction from prior radiation therapy, toxoplasmosis, urine discoloration (red/orange), others.
How is DOXIL supplied?
Single-use vials (10mL, 30mL)—6