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CYTOXAN INJECTION

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Generic Name for CYTOXAN INJECTION

Cyclophosphamide 500mg, 1g, 2g; per vial; pwd for inj after reconstitution; preservative-free.

Legal Classification:

Pharmacological Class for CYTOXAN INJECTION

Alkylating agent.

Manufacturer of CYTOXAN INJECTION

Bristol-Myers Squibb

Indications for CYTOXAN INJECTION

Adenocarcinoma of the ovary.

Other Indications for CYTOXAN INJECTION

Breast cancer

CNS cancers

Eye cancer

Leukemias, lymphomas, and other hematologic cancers

Adult dose for CYTOXAN INJECTION

Initially 40–50mg/kg IV in divided doses over 2–5 days; or 10–15mg/kg IV every 7–10 days; or 3–5mg/kg IV twice weekly.

Children's dosing for CYTOXAN INJECTION

See literature.

Also:

Cyclophosphamide

Contraindications for CYTOXAN INJECTION

Severe bone marrow depression.

Warnings/Precautions for CYTOXAN INJECTION

Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions for CYTOXAN INJECTION

Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.

Adverse Reactions for CYTOXAN INJECTION

GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.

Notes for CYTOXAN INJECTION

Tabs formerly known under the brand name Cytoxan.

How is CYTOXAN INJECTION supplied?

Tabs—contact supplier
Single-use vial—1

Related Disease:

Cancer, breast

Cancer, ovarian

Leukemia

Lymphoma, malignant

Multiple myeloma

Mycosis fungoides~antineoplastics

Neuroblastoma

Data provided by the Monthly Prescribing Reference (MPR) Hematology/Oncology Edition.

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Fluorouracil 50mg/mL; soln for IV inj.

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Pamidronate disodium 30mg; per vial; pwd for IV infusion after reconstitution; contains mannitol.

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Oncology > Breast cancer

Fluoxymesterone 10mg; tabs.

HALAVEN

Oncology > Breast cancer

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Oncology > Breast cancer

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