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Cyclophosphamide

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Generic Name for Cyclophosphamide

Cyclophosphamide 25mg, 50mg; tabs.

Legal Classification:

Pharmacological Class for Cyclophosphamide

Alkylating agent.

Manufacturer of Cyclophosphamide

Various generic manufacturers

Indications for Cyclophosphamide

Adenocarcinoma of the ovary.

Other Indications for Cyclophosphamide

Breast cancer

CNS cancers

Eye cancer

Leukemias, lymphomas, and other hematologic cancers

Adult dose for Cyclophosphamide

Initial and maintenance: 1–5mg/kg/day.

Children's dosing for Cyclophosphamide

See literature.

Also:

CYTOXAN INJECTION

Contraindications for Cyclophosphamide

Severe bone marrow depression.

Warnings/Precautions for Cyclophosphamide

Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions for Cyclophosphamide

Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.

Adverse Reactions for Cyclophosphamide

GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.

Notes for Cyclophosphamide

Tabs formerly known under the brand name Cytoxan.

How is Cyclophosphamide supplied?

Tabs—contact supplier
Single-use vial—1

Related Disease:

Cancer, breast

Cancer, ovarian

Leukemia

Lymphoma, malignant

Multiple myeloma

Mycosis fungoides~antineoplastics

Neuroblastoma

Data provided by the Monthly Prescribing Reference (MPR) Hematology/Oncology Edition.

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Bisphosphonates Cut Skeletal Morbidity in Multiple Myeloma

May 18, 2012

Zoledronate superior to placebo or etidronate for improving overall survival.

INTRON A

Oncology > Leukemias, lymphomas, and other hematologic cancers

Interferon alfa-2b, recombinant; 10million, 18million, or 50million IU per vial; pwd; for inj after reconstitution/dilution; preservative-free.

ISTODAX

Oncology > Leukemias, lymphomas, and other hematologic cancers

Romidepsin 10mg/vial; pwd for IV infusion after reconstitution and dilution; contains povidone.

TAXOTERE

Oncology > Breast cancer

Docetaxel 40mg/mL; soln for IV infusion after dilution; contains polysorbate 80; diluent contains alcohol.

Vinblastine for injection

Oncology > Prostate and other male cancers

Vinblastine (as sulfate) 10mg/vial; lyophilized pwd for IV inj or infusion after reconstitution.

VOTRIENT

Oncology > Bladder, kidney, and other urologic cancers

Pazopanib 200mg, 400mg; tabs.

Oncology > Cytoprotective and supportive care agents

Bisphosphonates (eg, Aredia, Zometa) may inhibit the activation of cancer-associated proteins through the suppression of geranyl-geranylation and farnesylation or inhibit ...
more »

'Teachable Moments' for Smoking Cessation in Patients Diagnosed with Cancer Underutilized

Debra Hughes February 16, 2012

Less than one-fifth (18.1%) of healthcare providers reported high levels of confidence in their ability to counsel patients with cancer who smoke to quit smoking, a survey published in The Oncologist online February 14 has found.