Generic Name for COSMEGEN
Dactinomycin 500mcg/vial; lyophilized pwd for IV inj or regional perfusion after reconstitution; contains mannitol; preservative-free.
Legal Classification:
Rx
Pharmacological Class for COSMEGEN
Actinomycin antibiotic.
Manufacturer of COSMEGEN
Lundbeck Inc.
|
Indications for COSMEGEN
Gestational trophoblastic neoplasia.
Other Indications for COSMEGEN
Adult dose for COSMEGEN
Give by IV infusion. 12mcg/kg daily for 5 days as a single agent; 500mcg on Days 1 and 2 as combination regimen with etoposide, methotrexate, folinic acid, vincristine, cyclophosphamide, and cisplatin. Max 15mcg/kg/day per 2-week cycle or 400–600mcg/m2/day for five days. Use surface area to calculate dose for obese or edematous patients.
Children's dosing for COSMEGEN
See literature.
Contraindications for COSMEGEN
Current or recent chickenpox or herpes zoster.
Warnings/Precautions for COSMEGEN
Myelosuppression; monitor bone marrow and hold treatment if platelets or WBCs decrease markedly. Extremely corrosive; avoid extravasation. Avoid skin, mucous membranes, eyes. Previous irradiation (esp. within 2 months of irradiation for treatment of right-sided Wilms' tumor), cytotoxic chemotherapy. Monitor renal and hepatic function. Obese. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Interactions for COSMEGEN
Avoid live vaccines. Concomitant radiotherapy in Wilms' tumor: not recommended.
Adverse Reactions for COSMEGEN
GI upset, stomatitis, bone marrow suppression (neutropenia, thrombocytopenia), liver toxicity, infusion site reactions, malaise, fatigue, alopecia, possible second primary tumors (including leukemia); for perfusion therapy: infection, impaired wound healing, superficial ulceration of gastric mucosa, edema, soft tissue damage, possible venous thrombosis.
How is COSMEGEN supplied?
Vials—1