Generic Name for Cisplatin
Cisplatin 1mg/mL; soln for IV infusion after dilution.
Legal Classification:
Rx
Pharmacological Class for Cisplatin
Platinum coordination complex.
Manufacturer of Cisplatin
Various generic manufacturers
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Indications for Cisplatin
As a single agent, for secondary therapy of metastatic ovarian tumor. Adjunctive therapy for ovarian tumor.
Other Indications for Cisplatin
Adult dose for Cisplatin
Give by IV infusion over 6–8 hours. 100mg/m2 IV per cycle once every 4 weeks; or, (when given with cyclophosphamide): 75–100mg/m2 IV per cycle once every 4 weeks. Usual max: 100mg/m2 per cycle. Subsequent cycles: give as tolerated, withhold dose if serum creatinine, BUN, platelets, WBCs, or auditory acuity out of normal limits; see literature.
Children's dosing for Cisplatin
Not recommended.
Contraindications for Cisplatin
Renal or hearing impairment. Myelosuppression. Pregnancy (Cat.D). Nursing mothers.
Warnings/Precautions for Cisplatin
Have epinephrine, antihistamine available. Monitor baseline and pre-treatment renal function, electrolytes, auditory function; do periodic CBCs (weekly), liver function tests, neurologic exam. Hydrate patient before dosing. Avoid extravasation. Elderly.
Interactions for Cisplatin
Potentiates nephrotoxicity with other nephrotoxic drugs (eg, aminoglycosides). May antagonize anticonvulsants. May be antagonized by pyridoxine.
Adverse Reactions for Cisplatin
Nephrotoxicity, neurotoxicity (eg, peripheral neuropathies), ototoxicity, myelosuppression, hemolytic anemia, marked nausea and vomiting, vascular toxicity (eg, MI, TIA), electrolyte disturbances, hyperuricemia, SIADH, hepatotoxicity, anaphylactic-like reactions, others; see literature.
How is Cisplatin supplied?
Contact supplier.