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ADRIAMYCIN SOLUTION

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Compare ADRIAMYCIN SOLUTION to:

Generic Name for ADRIAMYCIN SOLUTION

Doxorubicin HCl 2mg/mL; soln for IV inj.

Legal Classification:

Pharmacological Class for ADRIAMYCIN SOLUTION

Anthracycline antibiotic.

Manufacturer of ADRIAMYCIN SOLUTION

Bedford Laboratories

Indications for ADRIAMYCIN SOLUTION

Disseminated neoplasias (eg, ovarian carcinoma).

Adults and Children:

Monotherapy: usually 60–75mg/m² IV every 21 days. Combination therapy: usually 40–60mg/m² IV every 21 to 28 days. Hyperbilirubinemia, inadequate bone marrow reserves: reduce dose.

Also:

ADRIAMYCIN

Contraindications for ADRIAMYCIN SOLUTION

Severe myelosuppression (baseline neutrophils <1500cells/mm³) or severe hepatic impairment. Cardiac disease (eg, severe myocardial insufficiency, arrhythmias). Recent MI. Previous treatment with max cumulative doses of anthracyclines, anthracenediones.

Warnings/Precautions for ADRIAMYCIN SOLUTION

Pre-existing heart disease or risk thereof. Obtain baseline CBC, bilirubin, AST, creatinine, LVEF. Hepatic dysfunction. Monitor cardiac function (LVEF, ECG echocardiogram), hepatic function, CBC, uric acid levels. Avoid extravasation. Children (cardiotoxicity, impaired myocardial growth). Elderly. Pregnancy (Cat.D; use adequate contraception). Nursing mothers: not recommended.

Interactions for ADRIAMYCIN SOLUTION

See Contraindications. Mediastinal irradiation, cyclophosphamide, calcium channel blockers, other anthracyclines increase risk of cardiac toxicity; limit lifetime dose to 400mg/m². Necrotizing colitis with cytarabine. May increase toxicity of cyclophosphamide, mercaptopurine. May reduce serum digoxin levels. Doxorubicin toxicity increased with high-dose IV progesterone, cyclosporine, streptozocin, and if given after paclitaxel infusion (give doxorubicin dose first). Elimination increased by phenobarbital. May decrease phenytoin levels. Recall pneumonitis with actinomycin and radiation in children.

Adverse Reactions for ADRIAMYCIN SOLUTION

Local necrosis if extravasation occurs, myocardial toxicity (immediate or delayed), arrhythmias, leukemia, myelosuppression, hyperuricemia, urine discoloration, alopecia, hyperpigmentation, severe GI upset/ulceration, phlebosclerosis, facial flushing, fever, urticaria, peripheral neuropathy, anaphylaxis.

How is ADRIAMYCIN SOLUTION supplied?

Vials (10mg, 20mg)—10
Vials (50mg)—1
Soln (5mL, 10mL, 25mL)—10
Soln (100mL)—1 (multidose vial)

Related Disease:

Cancer, bladder

Cancer, breast

Cancer, GI

Cancer, lung

Cancer, ovarian

Cancer, thyroid

Hodgkin's disease

Leukemia, acute lymphoblastic

Leukemia, acute myeloblastic

Lymphoma, malignant

Sarcoma, bone

Sarcoma, soft tissue

Wilms' tumor

Data provided by the Monthly Prescribing Reference (MPR) Hematology/Oncology Edition.

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Debra Hughes May 18, 2012

Young adult males and females with cancer receive vastly different amounts of fertility-related and fertility preservation information.

STAT3 Mutations ID'd in Rare Lymphoproliferative Disorder

May 18, 2012

Four specific mutations in SH2 domain seen in T-cell large granular lymphocytic leukemia.

Genetic Profiling Improves Prognosis of Uveal Melanoma

James Netterwald, PhD May 18, 2012

Gene expression profiling (GEP) and chromosomal analysis show prognostic value in patients with uveal melanoma.

Bisphosphonates Cut Skeletal Morbidity in Multiple Myeloma

May 18, 2012

Zoledronate superior to placebo or etidronate for improving overall survival.

ADRIAMYCIN

Oncology > Leukemias, lymphomas, and other hematologic cancers

Doxorubicin HCl 10mg/vial, 20mg/vial, 50mg/vial; pwd for IV inj after reconstitution; contains lactose.

GLEEVEC

Oncology > Colorectal and other GI cancers

Imatinib (as mesylate) 100mg, 400mg; tabs.

Methotrexate injection

Oncology > Breast cancer

Methotrexate 25mg/mL; soln for IV, IM, intra-arterial, or intrathecal administration after dilution; preservative-free.

Tamoxifen

Oncology > Breast cancer

Tamoxifen (as citrate) 10mg, 20mg; tabs.

THYROGEN

Oncology > Pancreatic, thyroid, and other endocrine cancers

Thyrotropin alfa 1.1mg/vial; lyophilized pwd for IM inj after reconstitution; contains mannitol.

Oncology > Cytoprotective and supportive care agents

Bisphosphonates (eg, Aredia, Zometa) may inhibit the activation of cancer-associated proteins through the suppression of geranyl-geranylation and farnesylation or inhibit ...
more »

'Teachable Moments' for Smoking Cessation in Patients Diagnosed with Cancer Underutilized

Debra Hughes February 16, 2012

Less than one-fifth (18.1%) of healthcare providers reported high levels of confidence in their ability to counsel patients with cancer who smoke to quit smoking, a survey published in The Oncologist online February 14 has found.