Swallow whole on empty stomach. Initially 30mg once daily. Usual maintenance: 30–60mg once daily. Titrate over 7–14 days; max 90mg/day.
Calcium channel blocker (dihydropyridine).
Aortic stenosis. Angina. Severe obstructive coronary artery disease. Heart failure. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Potentiates antihypertensives, digoxin, tacrolimus. Angina and heart failure possible with β-blockers. Potentiated by cimetidine, doxazosin, ketoconazole, valproic acid, grapefruit juice, other CYP3A4 inhibitors. Antagonized by rifampin, phenytoin, carbamazepine, St. John's wort, other CYP3A4 inducers. Monitor oral anticoagulants, quinidine. Hypotension possible with fentanyl.
Peripheral edema, headache, flushing, dizziness, fatigue, constipation, muscle cramps, rash; exacerbation of angina, heart failure (rare).
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